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최선심 교수

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최선심 교수
학력
  • 학사: 이화여자대학교 과학교육(생물전공) 1988.3-1992.2
  • 석사: 포항공과대학교 생명과학과 1992.3-1994.2
  • 박사: 포항공과대학교 생명과학과 1994.3-1998.2
주요경력
  • 박사후과정, 포항공대, 1998. 2-2000. 2
  • 선임연구원, 바이오인포메틱스㈜, 2000.9-2002.3
  • 박사후과정, 시카고대학 (U of Chicago), 2002.4-2006.8
연구분야
  • Evolutionary genomics, Molecular evolution, Systems bioinformatics
연구실적
 논문
  • Lee EK, Hong SH, Shin S, Lee HS, Lee JS, Park EJ, Choi SS, Min JW, Park D, Hwang JA, Johnson BH, Jeon SH, Kim IH, Lee YS, Lee YS (2016) nc886, a non-coding RNA and suppressor of PKR, exerts an oncogenic function in thyroid cancer. Oncotarget doi: 10.18632/oncotarget.11852
  • Park DH, Huh HJ, Kim YJ, Son DS, Jeon HJ, Im EH, Kim JW, Lee NY, Kang ES, Kang CI, Chung DR, Ahn JH, Peck KR, Choi SS, Kim YJ, Ki YJ, Ki CS, Park WY (2016) Analysis of intra-patient heterogeneity uncovers the microevolution of Middle East respiratory syndrome coronavirus. Mol Case Stud doi: 0.1101/mcs.a001214
  • Jo BS, Koh IU, Bae JB, Yu HY, Jeon ES, Lee HY, Kim JJ, Choi M, and Choi SS (2016) Data of methylome and transcriptome derived from human dilated cardiomyopathy. Data in Brief 10.1016/j.dib.2016.09.006
  • Lee EK, Hong SH, Shin S, Lee HS, Lee JS, Park EJ, Choi SS, Min JW, Park D, Hwang JA, Johnson B, Jeon SH, Kim IH, Lee YS, and Lee Y (2016). nc886, a non-coding RNA and suppressor of PKR, exerts an oncogenic function in thyroid cancer. Oncotarget (in press)
  • Jo BS, Koh IU, Bae JB, Yu HY, Jeon ES, Lee HY, Kim JJ, Choi M, and Choi SS (2016) Methylome analysis reveals alterations in DNA methylation in the regulatory regions of left ventricle development genes in human dilated cardiomyopathy. Genomics 108, 84-92
  • Yang JY, Kim MS, Kim E, Cheon JH, Lee YS, Kim Y, Lee SH, Seo SU, Shin SH, Choi SS, Kim B, Chang SY, Ko HJ, Bae JW, Kweon MN (2016) Enteric Viruses Ameliorate Gut Inflammation via Tolllike Receptor 3 and Toll-like Receptor 7-Mediated Interferon-b Production. Immunity doi:10.1016/j.immuni.2016.03.009
  • An HJ, Lee HJ, Jang S, Jung YJ, Choi SS, Park SC (2016) Transcription factor Sp1 prevents TRF2-induced premature senescence in human diploid fibroblasts. Mol Cell Biochem 2016 Mar;414(1-2):201-8.doi:10.1007/s11010-016-2672-7
  • Min JW, Choi SS (2015) Expressional Subpopulation of Cancers Determined by G64, a Co-regulated Module. Genomics Inform 2015;13(4):132-136
  • Jo BS, Choi SS (2015) Introns: The Functional Benefits of Introns in Genomes. Genomics Inform 2015;13(4):112-118
  • Min J-W, Kim WJ, Han JA, Jung Y-J, Kim K-T, Park W-Y, Lee H-O, Choi SS (2015) Identification of Distinct Tumor Subpopulations in Lung Adenocarcinoma via Single-Cell RNA-seq. PLoS ONE 10(8): e0135817.doi:10.1371/journal.pone.0135817   
  • Shin SH, Choi SS (2015) Lengths of coding and noncoding regions of a gene correlate with gene essentiality and rates of evolution. Genes & Genomics 37: 365-374
  • Lee HJ, Kim KC, Hahn JA, Choi SS, Jung YJ (2015)The Early Induction of Suppressor of Cytokine Signaling 1 and the Downregulation of Toll-like Receptors 7 and 9 Induce Tolerance in costimulated Macrophages. Molecules and cells 38: 26-32.

  • Lee HY, Han SS, Rhee H, Park JH, Lee JS, OH YM, Choi SS,Shin SS, Kim WJ (2015) Differential expression of miRNAs and their target genes in non-small-cell lung cancer. Molecular Medicine Reports 11: 2034-2040
  • Jung JI, Cho HJ, Jung YJ, Kwon SH, Her Song, Lee KW,Shin SH, Choi SS, and Park J (2015). High-fat diet-induced obesity increases lymphagiogenesis and lymph node metastasis in the B16F10 melanoma allograft model: Roles of adipocytes and M2-macrophages. International journal of Cancer 136: 258-270.

  • Park SG, Hannenhalii S, and Choi SS (2014)Conservation in first introns is positively correlated with the number of exons within genes and the presence of regulatory epigenetic signals. BMC genomics 15:526
  • Oh J, Rho HS, Yang Y, Yoon JY, Lee J, Hong YD, Kim HC, Choi SS, Kim TW, Shin SS, Cho JY (2013) Extracellular Signal-Regulated Kinase Is a Direct Target of the Anti-Inflammatory CompoundAmentoflavone Derived from Torreya nucifera. Mediators of inflammation : 11 pages

  • Choi SS and Hannenhalli S (2013) Three independent determinants of protein evolutionary rate. J. Mol. Evol. 76: 98-111

  • Yang H, Ko HJ, Yang JY, Kim JJ, Seo SK, Park SG, Choi SS, Seong JK and Kweon MN (2013) Interleukin-1 promotes coagulation which is necessary for protective immunity in the lung against Streptococcuspneumoniae infection. The Journal of Infectious Disease 207: 50-60
  • Cho H, Han S, Choe J, Park SG, Choi SS, Kim YK(2013) SMG5-PNRC2 is a functionally dominant complex in mammaliannonsense-mediated mRNA decay. NucleicAcids Res 41:1319-1328

  • Lee ME, Kim SR, Lee S, Jung YJ, Choi SS, Kim UJ,and Han JA (2012) Cyclooxygenase-2 inhibitors modulate skin aging in acatalytic activity-independent manner. ExpMol Med. 44(9):536–544.

  • Cho H, Kim KM, Han S, Choe J, Park SG, ChoiSS, and Kim YK (2012). Staufen1-mediatedmRNA decay functions in adipogenesis. Molecular cell 46, 495-506

  • Park SG, Kwon KH, and Choi SS (2012).Analysis of putative miRNA function using a novel approach, GAPPS-miRTARGE. Genes and Genomics 34, 205-216.

  • MokYJ, Park SG, and Choi SS (2012). Comparative analysis of the structural and expressional parameters of miRNA target genes. Gene 497, 103-109.

  • Lee SY, Lee YG, ByeonSE, Han S, Choi SS, Kim AR, Lee J, Lee SJ, Hong S, and Cho JY (2010). MitogenActivated Protein Kinases are Prime Signalling Enzymes in Nitric OxideProduction Induced by Soluble β-Glucanfrom Sparassis crispa. ArchPharm Res 11, 1753-1760.

  • Park SG and Choi SS(2010). Expression breadth and expression abundance behave differently incorrelation with evolutionary rates. BMC evolutionary biology 10: 241

  • Choi SS, Chung EK, and Jung YJ (2010). NewlyIdentified CpG ODNs, M5-30 and M6-395, stimulate mouse immune cells to secreteTNF-a and enhance Th-1 mediated immunity. TheJournal of Microbiol. 48: 512-517

  • Choi SS (2010). The frequency of neural stem cells inin vitro culture systems: insights from simple modeling. Genes and Genomics 32:225-231

  • You DS, Lee J, Choi SS, Rho HS, Cho DH, ShinWC, Cho JY (2010). A modulatory effect of novel kojic acid derivatives oncancer cell proliferation and macrophage activation.  Pharmazie 65. 261-266

  • Park D, Choi SS,Ha KS (2010). Transglutaminase 2: a multi-functional protein in multiplesubcellular compartments.  Amino acids 39:619-631

  • Park SG, Park D, JungYJ, Jung EK, Choi SS (2010). Positive selection signature in the TLR7family. Genes and Genomics 32:143-150

  • Sun Shim Choi (2009)Controversies on the rates of protein evolution. Interdisplinary Bio Central 11:1-5

  • Yi JY, Jung YJ, Choi SS, Chung E (2009) TNF-alphadownregulates E-cadherin and sensitizes responses to gamma irradiation inCaco-2 cells. Cancer Res Treat 41:164-70

  • Yi JY, Jung YJ, Choi SS, Hwang J, ChungE (2009) Autophagy-mediated antitumoral activity of imiquimod in Caco-2 cells. BBRC 386, 455-8

  • Park D, Xiang AP, Mao FF, Walton NM, Choi SS,Lahn BT (2009) The radial glia antibody RC2 recognizes a protein encoded byNestin. BBRC 382, 588-92

  • Park D, Park J, ParkSG, Park T, Choi SS (2008) Analysis of human disease genes in thecontext of gene essentiality. Genomics 92, 414-418.

  • Kwon, Y.K., ChoiS.S., Cho, K.H. (2007) Investigations into the relationship betweenfeedback loops and functional importance of a signal transduction network basedon Boolean network modeling. BMCBioinformatics 8, 384

  • Choi,S.S., Vallender, E.J.,Lahn, B.T. (2006) Systematically Assessing the Influence of Three-DimensionalStructural Context on the Molecular Evolution of Mammalian Proteomes. Mol.Biol. Evo. 23:2131-2133

  • Choi, S.S., Bush, E. Lahn, B.T. (2006). Different classes of tissue-specific genes show different levels of noncoding conservation. Genomics 87:433-436.

  • Choi, S.S.,Li, W., Lahn, B.T (2005). Robust signals of coevolution of interacting-residuein mammalian proteomes identified by phylogeny-aided structural analysis. Nature Genet. 12:1367-1371

  • Dorus, S., Evans, P.D., Wyckoff, G.J., Choi, S.S., & Lahn,B.T. (2004). Rate of molecular evolution of the seminal protein gene SEMG2 correlates with levels of female promiscuity. Nature Genet. 36:1326-1329.

  • Hong, S.H., Kim, J.S., Lee, S.Y., In, Y.H.,Choi, S.S., Rih, J.-K., Kim, C.H., Jeong, H.Y., Hur, C.G., & Kim,J.J. (2004) The genome sequence of the capnophilic rumen bacterium Mannheimiasucciniciproducens. Nature Biotech. 22: 1275-1281.

  • Evans,P.D., Anderson,J.R., Vallender, E.J., Choi, S.S., Lahn, B.T. (2004).  Reconstructing the evolutionary history of Microcephalin, a gene controlling human brain size.Hum Mol Genet. 13:1139-1145.

  • Choi, S.S.,Lahn, B.T. (2003). Adaptive evolution of MRG, a neuron-specific gene family implicated in nociception. Genome Res 13: 2252-2259.
  • Choi,S.S.,Kang, Y.S., Kim, U.-J., Lee, K.H., Shin, H.-S. (1999). Chromosomal localization of ESTs from human fetal liver via BAC-mediated FISH mapping. Mol. Cells 9: 403-409.

  • Jung-Ha, H., Kim, D., Lee, S.-B., Hong, S.-I., Park,S.-Y., Huh, J., Kim, C.-W., Kim S.-S., Lee, Y., Choi, S.S., Shin, H.-S.(1998). Expression of Bfl-1 in Normaland Tumor Tissues: Bfl-1 Overexpression in cancer due to its preferentialexpression in infiltrating inflammatory cells. Human pathology 29:723-728.
  • Park,I.C., Lee, S.H., Whang, D.Y., Hong, W.S., Choi, S.S., Shin, H.S., Chae,T.B., Hong, S.I (1997). Expression of a novel Bcl-2-related gene, Bfl-1, invarious human cancers & cancer cell lines. Anticancer Res. 17, 4619-4622.

  • Choi,S.S.,Park, S.H., Kim, U.-J., Shin, H.-S. (1997). Bfl-1, a Bcl-2-related gene, is thehuman homolog of the murine A1, and maps to Chromosome 15q24.3. Mamm. Genome 8, 781-782.

  • Kim,U.-J., Shizuya, H., Kang, H.-L., Choi, S.S., Garrett, C.L., Smink, L.J.,Birren, B.W., Korenberg, J.R., Dunham, I., and Simon, M.I. (1996). A bacterialartificial chromosome-based framework contig map of human chromosome 22q. Proc.Natl. Acad. Sci. USA 93: 6297-6301.

  • Choi,S.S.,Yun, J.W., Choi, E.K., Cho, Y.G., Sung, Y.C., Shin, H.-S. (1995b). Construction of a gene expression profile of a human fetal liver by single-pass cDNAsequencing. Mamm. Genome 6, 653-657.

  • Choi,S.S.,Park, I.C., Yun, J.W., Sung, Y.C., Hong, S.I., Shin, H.-S. (1995a). A novelBcl-2 related gene, Bfl-1, is overexpressed in stomach cancer andpreferentially expressed in bone marrow. Oncogene 11, 1693-1698.

  단행본
  • BT e-Learning Practical English, 김남수, 이세원, 조동하, 김명동, 안주희, 최선심, 박용철 저, 강원대학교 출판부 (2009)
  • 생명공학실험서, 박철호, 심태흠, 안철, 왕명현, 이해익, 조재열, 최선심, 최신건, 최신욱, 최용순 저, 강원대학교 출판부 (2009)

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